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Oxycodone is effective for managing moderate to moderately severe acute or chronic pain. It has been found to improve quality of life for those with many types of pain.
Oxycodone can also be used as a alternative to other opiates to treat severe diarrhea and diarrhea predominant irritable bowel syndrome when drugs such as loperamide and diphenoxylate are ineffective.
In 2001 the European Association for Palliative care recommended that oral oxycodone be a second-line alternative to oral morphine for cancder pain. There is no evidence that any opioids are superior to morphine in relieving the pain of cancer, and no controlled trials have shown oxycodone to be superior to morphine. However, compared to morphine, oxycodone causes less respiratory depression, sedation, pruritus, and nausea. As a result, it is generally better tolerated than morphine.
The most commonly reported effects include memory loss,constipation,fatigue, dizzeness, nausea, lightheadedness, headache, dry mouth, aniety, itching, and heavy sweating. It has also been claimed to cause dimness in vision due to mioses. Some patients have also experienced loss of appetite, nervousness, abdominal pain,diarrhea, urine retention,dyspnea and hiccups, although these symptoms appear in less than 5% of patients taking oxycodone. Rarely, the drug can cause impotence, enlarged prostate gland and decreased testorone secretion.
In high doses, overdoses, or in patients not tolerant to opiates, oxycodone can cause shallow breathing,bradycardia, cold, clammy skin,apnea,hypotension, miosis (pupil constriction),circulatory collapse,respiratory arrest, and death.